Sijie Chen

Synergistic interactions between Bacteroides intestinalis and Arabinoxylan Mitigates Inflammatory and Metabolic Dysfunction

This study shows that pairing Bacteroides intestinalis with arabinoxylan reduces inflammation and metabolic issues in mice by altering metabolism and gene expression.

Translational Fidelity Maintained by ZNF598-Dependent Ribosome Resolution Enables Cellular Adaptation to High Energy Demand

This study identifies ZNF598 as a factor resolving translation stress during metabolic adaptation, showing its role in mitochondrial biogenesis and metabolic flexibility.

Interpreting variants associated with congenital heart disease with a regulatory map of the human fetal heart

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

The paper identifies PTBP1's role in regulating alternative splicing of actin regulators to control Sertoli cell actin cytoskeleton dynamics during spermatogenesis.

Phase transition of maternal RNAs during vertebrate oocyte-to-embryo transition

The paper identifies maternal RNA phase transitions during Xenopus oocyte-to-embryo transition, showing distinct soluble and insoluble states and their conservation in zebrafish.