Min Li

scHiR learns joint cellular representations from paired single-cell transcriptome and 3D genome data

scHiR learns joint representations from paired scRNA-seq and scHi-C data, improving clustering and trajectory inference while recovering input signals.

Unified modeling of mutation-induced protein stability responses with OmegaTherm

OmegaTherm predicts mutation-induced protein stability responses by jointly modeling folding free energy and melting temperature, achieving state-of-the-art performance in prediction and variant ranking.

Predicting Pre-treatment Resistance or Post-treatment Effect? A Systematic Benchmarking of Single-Cell Drug Response Models

This study benchmarks single-cell drug response models across 26 datasets, showing performance varies with dataset type, imbalance, and model design, with scDEAL showing competitive results.

High-salt diet disturbs the physiological uterine endothelial junction remodeling during pregnancy

This study shows that a high-salt diet disrupts uterine endothelial junction remodeling during pregnancy, leading to hypertension and adverse outcomes in mice.

Synergistic interactions between Bacteroides intestinalis and Arabinoxylan Mitigates Inflammatory and Metabolic Dysfunction

This study shows that pairing Bacteroides intestinalis with arabinoxylan reduces inflammation and metabolic issues in mice by altering metabolism and gene expression.

Evolutionary predisposition of NIN to function in nitrogen-fixing nodules

The paper shows that non-symbiotic NIN orthologs can function in nodule initiation and infection, indicating NIN was predisposed for symbiosis before nodulation evolved.

TopoLa: A Universal Framework to Enhance Cell Representations for Single-cell and Spatial Omics through Topology-encoded Latent Hyperbolic Geometry

TopoLa enhances cell representations in single-cell and spatial omics by using topology-encoded latent hyperbolic geometry, improving performance across multiple tasks.

A Novel 'Three-in-one' Mucosal Vaccine Elicits Broad Protection against Three Distinct Clusters of ACE2-using Sarbecoviruseses

This paper develops a three-in-one mucosal vaccine, 3Rs-NC, that elicits broad neutralizing antibodies against three ACE2-using sarbecovirus clusters and provides durable protection in mice.

Comparative Analysis of Phytochemical Constituents of Ginkgo Biloba Flowers and Leaves, and Evaluation of Their Biological Activities

This study compares the chemical and nutritional composition of Ginkgo biloba flowers and leaves, finding flowers richer in bioactive compounds and showing superior anti-radiation and anti-ferroptosis activity.

Enhancing Strain-level Phage-Host Prediction through Experimentally Vali-dated Negatives and Feature Optimization Strategies

This study improves strain-level phage-host prediction by using experimentally validated negatives and optimized features, showing better performance with protein-based features and experimental negatives.

Activation of NLRP3 inflammasome/pyroptosis by protease inhibitor atazanavir at high concentrations is mediated through mitochondrial dysfunction

This study shows high concentrations of atazanavir induce mitochondrial dysfunction and NLRP3 inflammasome/pyroptosis in T cells, leading to apoptosis.

Trio deep-sequencing does not reveal unexpected mutations in Cas9-edited monkeys

The paper uses whole genome trio sequencing to assess off-target effects of Cas9 editing in monkeys and finds no unexpected mutations.

MinE recruits, stabilizes, releases, and inhibits MinD interactions with membrane to drive oscillation

The paper investigates how MinE regulates MinD membrane interactions to drive oscillatory patterns in E. coli, refining a toggle switch model for pattern formation.