José Francisco Martı́nez

This study identifies ZNF598 as a factor resolving translation stress during metabolic adaptation, showing its role in mitochondrial biogenesis and metabolic flexibility.

The paper identifies ZAKα as a sensor that detects mRNA stasis at the ribosomal exit channel through interactions with ribosomal proteins and rRNA.

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.