Molecular BiologybioRxivPreprint
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Fereshteh Dorazehi, Caterina Francesconi, Ninoslav Pandiloski…·Christopher H. Douse
This study shows MORC2 regulates CpG methylation of active LINE-1 retrotransposons during human neurodevelopment, similar to the piRNA pathway in the germline.
DOI 10.1101/2025.06.11.658943