Xi Wang

Multi-Criteria Evaluation of Hibiscus mutabilis Cultivars for Food Development Using Delphi and Analytic Hierarchy Process

This study evaluates 11 Hibiscus mutabilis cultivars for food use using Delphi and AHP, identifying three top cultivars for food development.

From deserts to forests: sequencing of the giant forest hog completes the genomic history of the African Suids

This paper presents the first whole-genome data for the giant forest hog, revealing its evolutionary relationship with warthogs and significant genetic differentiation between populations.

MDA5 multimerization on LINE RNA drives pathogenic extracellular immune complexes in autoimmunity

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments

The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.

Trans-Kingdom dsRNA Sensing: Aspergillus fumigatus Mycovirus Activates MDA5/MAVS Immunity and Limits Allergic Bronchopulmonary Aspergillosis

The paper shows that dsRNA mycoviruses in Aspergillus fumigatus enhance MDA5/MAVS signaling and reduce virulence in chronic allergic aspergillosis.

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

G3DCT: An Interpretable Spatial Grid-based Framework with Temporal Convolution-Transformer for EEG Artifact Identification

G3DCT is a deep learning framework for EEG artifact identification that outperforms existing models, achieving a 2.8% F1-score improvement on combined artifacts.

Site-specific integration of transposon via engineered piggyBac transposase

This paper demonstrates a method using engineered piggyBac transposase and CRISPR/Cas9 to achieve targeted integration of large DNA fragments into the human genome with high specificity and efficiency.

Sex specific knee joint soft tissue mineralization with Fibrillin-1 mutation in male Tight Skin mice.

This study investigates sex-specific effects of Fibrillin-1 mutation on knee joint mineralization and osteoarthritis in TSK mice, finding increased pathology in males compared to females.

Mechanism of D-type cyclins recognition by the AMBRA1 E3 ligase receptor

The paper determines the cryo-EM structure of the AMBRA1-DDB1 complex bound to cyclin D1, revealing the molecular mechanism of cyclin D1 recognition and its regulation by phosphorylation.

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

A multicellular actin star network underpins epithelial organization and connectivity

This study identifies a multicellular actin star network in adult murine intestinal epithelium that maintains tissue stability and organization through mechanical and structural mechanisms.

Alpha activity neuromodulation induced by individual alpha-based neurofeedback learning in ecological context: A double-blind randomized study

This study investigates alpha activity neuromodulation through neurofeedback training in a double-blind randomized study, finding increased alpha activity only in the neurofeedback group.