The inactivation of DHHC7 in mouse liver promotes diet-induced obesity through a hepatic Prg4-GPR146 axis
Yingmin Sun, Ying Liu, Siyu Wang, Hanyu Wu, Xiaoli Hou, Jiaqi Duan, Junkai Pei, Yanhua Xu, Xiaoxiang Hu, Bing Chen
This study shows that inactivating DHHC7 in mouse liver leads to obesity via a Prg4-GPR146 axis, affecting adipose lipolysis and fat accumulation.
bioRxiv · Dec 31, 2025 · PreprintPhysiology