TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing
Mikhail V. Pogorelyy, Allison M. Kirk, Samir Adhikari, Anastasia A. Minervina, Balaji Sundararaman, Kasi Vegesana, David C. Brice, Zachary B. Scott, SJTRC Study Team, Joshua Wolf, Aditya H. Gaur, James M. Hoffman, Tomi Mori, Li Tang, ELAINE I. TUOMANEN, , Paul Glyndwr Thomas
TIRTL-seq provides a scalable, cost-effective method for paired TCR repertoire sequencing, enabling accurate identification of TCR chain pairings and clonotype dynamics in large cohorts.
Nature Methods · Nov 24, 2025Peer-reviewedImmunology