A. Green

Network-based framework for studying etiology and phenotype diversity in primary ciliopathies

This study uses network propagation to improve the clustering of primary ciliopathies and identify candidate genes, including a novel variant in CEP43.

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity

This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase.

The paper investigates structural models of the POR-Pchlide-NADPH ternary complex and proposes an alternative model based on mutagenesis and computational analysis, identifying key residues involved in catalysis.

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

This study shows nasal swabs can assess mucosal immune responses to SARS-CoV-2, revealing distinct cytokine and antibody profiles compared to systemic responses.

Establishing thresholds for cytokine storm and defining their relationship to disease severity in respiratory viral infections

This study identifies cytokine thresholds and their relationship to disease severity in respiratory viral infections, showing that hypercytokinemia is not strongly linked to severity and that certain cytokines may predict long COVID risk.

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model

MRI-guided focused ultrasound with microbubbles increases panobinostat delivery and efficacy in a diffuse midline glioma mouse model, reducing tumor volume and improving survival.

Respiration-Triggered Olfactory Stimulation ReducesObstructive Sleep Apnea Symptoms Severity: A Prospective Pilot Study

This study tests respiration-triggered olfactory stimulation as a treatment for OSA, finding a significant reduction in AHI and ODI without sleep disruption.

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

Integrative Teaching of Metabolic Modeling and Flux Analysis with Interactive Python Modules

The paper develops interactive Python modules to teach metabolic modeling and flux analysis, showing improved learner competence and confidence after using the resources.

Inhibition of GCN5 decreases skeletal muscle fat metabolism during high fat diet feeding

This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.

Sustainable reference points for multispecies coral reef fisheries

The paper estimates sustainable reference points for multispecies coral reef fisheries using environmental data and assesses their status, finding that over half of jurisdictions have failed sustainability benchmarks.

TMAO Destabilizes RNA Secondary Structurevia Direct Hydrogen Bond Interactions

This study investigates how TMAO interacts with RNA hairpins using molecular dynamics simulations, revealing that TMAO destabilizes RNA via hydrogen bond interactions with solvent-exposed bases.

Disrupted Peyer's patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus

This study examines the impact of COVID-19 on ileal Peyer's patches, finding disrupted microanatomy and germinal centre atrophy independent of local viral load.

Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

This study shows that Pseudomonas aeruginosa uses host-derived polyamines, like spermidine, to enhance antimicrobial tolerance during infection, despite reduced susceptibility in vitro.

In vitro assessment of the virucidal activity of four mouthwashes containing Cetylpyridinium Chloride, ethanol, zinc and a mix of enzyme and proteins against a human coronavirus

This study assesses the virucidal activity of four mouthwashes against a human coronavirus surrogate, finding that 0.07% Cetylpyridinium Chloride mouthwash reduces viral counts by ≥3.0 log.

A three-dimensional Air-Liquid Interface Culture Model for the Study of Epstein-Barr virus Infection in the Nasopharynx

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

Discovery and biosynthesis of clostyrylpyrones from the obligate anaerobe Clostridium roseum

The paper discovers a new family of natural products, clostyrylpyrones, from Clostridium roseum and proposes their polyketide synthase-based biosynthesis mechanism.

Super elongation complex as a targetable dependency in diffuse midline glioma

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis

The paper uses sequence coevolution and structural analysis to model interaction specificity of clustered protocadherins and predict isoform-specific interactions.