J. Wolf

Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii GRAZ-2 from human feces

The paper isolates and characterizes two new Methanobrevibacter species from human feces, highlighting genomic and phenotypic differences.

Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer's disease

This study shows that Robo4 deletion increases neuroinflammation and impairs motor coordination in Alzheimer's disease mice, with effects dependent on AD mutations and brain region.

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

This study shows nasal swabs can assess mucosal immune responses to SARS-CoV-2, revealing distinct cytokine and antibody profiles compared to systemic responses.

Establishing thresholds for cytokine storm and defining their relationship to disease severity in respiratory viral infections

This study identifies cytokine thresholds and their relationship to disease severity in respiratory viral infections, showing that hypercytokinemia is not strongly linked to severity and that certain cytokines may predict long COVID risk.

Characterisation of fasting and postprandial NMR metabolites: insights from the ZOE PREDICT 1 Study

This study characterizes postprandial NMR metabolites in the ZOE PREDICT 1 cohort, showing significant inter- and intra-individual variability and strong correlations between fasting and postprandial measurements.

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100A8 and S100A9

This study identifies C/EBPδ as a key regulator of S100A8 and S100A9 expression through epigenetic mechanisms in monocytes, with implications for inflammatory diseases.

Patterns of regulatory divergence and gene expression in hybrids are associated with molecular evolution in species undergoing gene flow

The paper examines how gene expression and regulatory divergence in hybrids relate to molecular evolution in species with gene flow, finding that cis-regulatory divergence and transgressive expression contribute to reproductive isolation, while dominant expression buffers hybrid breakdown.

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

This study examines microglial morphology and axonal pathology in pigs with mild TBI over one year, finding persistent microglial morphological changes but no astrocyte reactivity or corpus callosum changes.

Intraspecific diversity of fission yeast mitochondrial genomes

This study analyzes the mitochondrial genome diversity of 192 S. pombe isolates, identifying 69 sequence types, two new introns, and two divergent clades, suggesting a split of ancestral lineages around 31 million generations ago.

Killer whale genomes reveal a complex history of recurrent admixture and vicariance

This study uses killer whale genomes to reveal complex population history with recurrent admixture and vicariance, showing genetic homogenization at lower latitudes and differentiation at high latitudes.

MYCN-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

This study shows that MYCN overexpression in neuroblastoma cells rewires metabolism, creating vulnerabilities that can be targeted with metabolic inhibitors.

Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching

This study investigates the self-assembly of mutant huntingtin exon-1 fragments into complex fibrillar structures, identifying two nucleation mechanisms and their role in fibril formation.

RAD sequencing and a hybrid Antarctic fur seal genome assembly reveal rapidly decaying linkage disequilibrium, global population structure and evidence for inbreeding

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ

The paper uses PRISMA to map C/EBPβ's PTM-dependent interactome, revealing interaction footprints and functional links to chromatin and RNA processing.