APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker
This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.
bioRxiv · Jul 23, 2025 · PreprintPhysiology