Author

Thomas Leonhardt

University of Oregon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Abigail E. CulleniD· 3 shared Ashley E. WalkeriD· 3 shared Nabil J. AlkayediD· 3 shared Mackenzie N. KehmeieriD· 2 shared Martin M. PikeiD· 2 shared Naly SetthavongsackiD· 2 shared Ainsley P Hogan· 1 shared Alexandra FamianoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersPhysiology

Abigail E. CullenORCID

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3 papers

Recent·Most cited

APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice

Mackenzie N. Kehmeier, Young Deanna Choi, Abigail E. Cullen, Benjamin Zimmerman, Thomas Leonhardt, Maddie Snyder, Tucker Cleveland, Naly Setthavongsack, Randy Woltjer, Martin M. Pike, Nabil J. Alkayed, Ashley E. Walker

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

bioRxiv · Jul 11, 2026 · PreprintNeuroscience

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice

Abigail E. Cullen, Emily H Reeve, Nicholas Winder, Grant D. Henson, Nayantara Arora, Thomas Leonhardt, Ainsley P Hogan, Sahana Krishna Kumaran, Naly Setthavongsack, Victoria Krajbich, Nabil J. Alkayed, Martin M. Pike, Randall L. Woltjer, Ashley E. Walker

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

bioRxiv · Aug 18, 2025 · PreprintPhysiology

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

bioRxiv · Jul 23, 2025 · PreprintPhysiology