BiophysicsAngewandte Chemie International EditionPeer-reviewed
Nanoscale Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease
Zhongyue Guo, Giulio Chiesa, Jiaze Yin…·Ji‐Xin Cheng
This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.