BioengineeringNucleic Acids ResearchPeer-reviewed
Machine Learning-Driven Optimization of Specific, Compact, and Efficient Base Editors via Single-Round Diversification
Mykyta Ielanskyi, Meng Wang, Lewis Scott…·Tyson Bowen
This paper develops novel base editors by diversifying TadA orthologs and using generative models to optimize specificity and efficiency.
DOI 10.1093/nar/gkag545