Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain
Qiwen Dong, Stephen Harper, Emma McSpadden, Sophie S Son, Marie-Maude Allen, Huaiying Lin, Rita C. Smith, Carolyn K. Metcalfe, Victoria Burgo, Che Woodson, Anitha Sundararajan, Amber R. Rose, Mary McMillin, David Moran, Jessica Little, , Eric G. Pamer
This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.
Cell Host & Microbe · Nov 27, 2024Peer-reviewedMicrobiology