Resolving the Activation Mechanism of the Human 20S Proteasome
Bryan D. Ryder, N. Yan, Danna Trejos-Vidal, Patricia Martínez-Botía, Julian R. Braxton, Andrew Lim, Hannah Felstead, Steve Andrews, Eric Tse, Arthur Alves de Melo, John Skidmore, Miguel A. Prado, Daniel R. Southworth, Jason E. Gestwicki
This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.
bioRxiv · Apr 15, 2026 · PreprintBiophysics