BiophysicsbioRxivPreprint
Resolving the Activation Mechanism of the Human 20S Proteasome
Bryan D. Ryder, N. Yan, Danna Trejos-Vidal…·Jason E. Gestwicki
This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.
DOI 10.64898/2026.04.13.718244