Bryan D. Ryder

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

The paper designs Hsp70 activators that dissolve intracellular condensates by modulating Hsp70 ATPase activity and promoting protein refolding.

The paper uses an in silico alanine scan method to identify energetically important interactions in tau amyloid fibrils and classifies structures using machine learning.

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.