NeurosciencebioRxivPreprint
Utilizing a cell culture based novel cellular thermal shift assay to understand the isoform-dependent thermal stability of ApoE variants
Rosemary J. Jackson, Steven E. Dierksmeier, Maryam A. Nishtar…·Bradley T. Hyman
The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.
DOI 10.64898/2026.06.09.730809