Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface
Han Wang, Yuxuan Luo, Sandeep Artham, Qianqian Wang, Yi Peng, Zixi Yun, Xinyue Li, Chen Wu, Zhenghao Liu, Kristen L. Weber-Bonk, Chun-Peng Pai, Yuan Cao, Jiangan Yue, Sunghee Park, Ruth A. Keri, , Sichun Yang
This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.
Molecular Cancer Therapeutics · Sep 10, 2025Peer-reviewedCancer Biology