Han Wang

Reverse engineering Lewy bodies suggests alpha-synuclein pathology as condensatopathy

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

Physics-Driven Zero-Shot Reconstruction of Isotropic 3D Fluorescence Microscopy under Undersampled Acquisition

This paper introduces DeepUI, a physics-driven framework that reconstructs isotropic 3D fluorescence images from undersampled axial data, achieving high performance even under challenging conditions.

Circadian clock gates retinal regeneration by orchestrating Cxcl12-dependent immune coordination

This study shows that the circadian clock regulates zebrafish retinal regeneration by controlling immune coordination via the Cxcl12-Cxcr4 axis.

Fluorescence anisotropy structured illumination microscopy for quantitative super-resolved mapping of cell microenvironment and cytoskeletal dynamics

This paper introduces FA-SIM, a super-resolution microscopy technique that quantitatively maps intracellular microenvironment and cytoskeletal dynamics with high accuracy and low phototoxicity.

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

Non-visual light modulates behavioral memory and gene expression in C. elegans

This study shows visible light affects behavioral memory and gene expression in C. elegans through a non-visual pathway involving cyp-14A5 and bZIP transcription factors.

Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior

A universal model for carbon dioxide uptake by plants

The paper develops a universal model for carbon dioxide uptake by plants using an evolutionary optimality hypothesis, showing it aligns with empirical data and predicts primary production across biomes.