Xinyue Li

Droplet-based organoid screens enable high-throughput identification of cancer vulnerabilities

This paper introduces a droplet-based organoid culture method for high-throughput screening of cancer vulnerabilities, identifying novel therapeutic targets in stomach cancer.

Generative Access to Make-on-Demand Chemical Space Enables Ultra-Large Virtual Screening

The paper introduces REAL-SWIT, a generative framework for ultra-large virtual screening that efficiently explores chemical space by generating molecules with favorable docking scores.

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience

This study shows that inhibiting histone deacetylases enhances neuronal resilience to stress by inducing a permissive transcriptional state and activating proteostasis pathways.

Adaptive Coding Explains the Paradoxical Relationship between hippocampus size and memory function in Alzheimer's Disease, Autism Spectrum Disorder, and PTSD

The paper develops an autoencoder model to explain the complex relationship between hippocampal size and memory function in Alzheimer's Disease, Autism Spectrum Disorder, and PTSD by simulating experience-dependent encoding.