Early life social isolation primes flies for more rapid TDP-43 dependent neurodegeneration later in life.
Swetha Murthygowda, Kyle Huyghue, Brissa Castillo, Fiona Gugala, Wanhe Li, Josh Dubnau
This study shows that early-life social isolation in flies accelerates TDP-43-related neurodegeneration later in life by enhancing mdg4 activation and pathologic propagation.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience