Josh Dubnau

This study shows that early-life social isolation in flies accelerates TDP-43-related neurodegeneration later in life by enhancing mdg4 activation and pathologic propagation.

This study investigates glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 model by expressing different components of the G4C2 repeat expansion.

The paper identifies genes regulating sleep-metabolism interactions in Drosophila LHLK neurons using single-cell sequencing and functional validation.

This study shows that TDP-43 pathology in mice triggers LINE-1 retrotransposon replication in motor cortex neurons and glia, leading to cell-intrinsic and non-cell autonomous programmed cell death.

This study shows that TDP-43 pathology in Drosophila glial cells causes systemic toxicity, which can be reduced by knocking down SF2/SRSF1.

The paper shows that endogenous retroviruses and TDP-43 proteinopathy form a feedback loop that drives the spread of neurodegeneration in a Drosophila model.

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

The paper identifies SF2/SRSF1 as a suppressor of TDP-43 toxicity in both neurons and glia through a Drosophila behavioral screen.

This study shows Drosophila gypsy retrotransposon can replicate via both intracellular retrotransposition and intercellular viral spread, depending on the presence of its envelope protein.

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.

The paper introduces CLEVR, a method to detect gypsy retrovirus replication in Drosophila, showing increased replication in aging flies and when RNAi is disrupted.

The paper profiles nuclear transcriptomes of seven neuronal subtypes in Drosophila mushroom bodies, identifying specific genes and molecular features across cell types.

The paper describes a computational framework to convert high-throughput DNA sequencing data into neural circuit connectivity using BOINC and applies it to pseudorabies virus experiments.

This paper shows that TDP-43 expression in Drosophila causes retrotransposon activation, leading to neurodegeneration through DNA damage and programmed cell death.