NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and X. laevis models
Mayanglambam Dhruba Singh, Matthew Jensen, Micaela C. Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani S. Iyer, Diego E. Rincón-Limas, Laura Anne Lowery, Santhosh Girirajan
This study identifies NCBP2 as a key modifier gene in the 3q29 deletion, showing it enhances developmental defects through disrupted apoptosis and cell cycle mechanisms in Drosophila and Xenopus models.
bioRxiv · Dec 4, 2019 · PreprintGenomics