Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells
C. A. Lareau, Y. Yin, K. Maurer, K. D. Sandor, G. Yagnik, J. Pena, J. C. Crawford, A. M. Spanjaart, J. C. Gutierrez, N. J. Haradvala, T. Abay, R. R. Stickels, J. M. Verboon, V. Liu, J. Southard, , A. T. Satpathy
The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.
bioRxiv · Aug 12, 2022 · PreprintImmunology