J. Pena

Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

This paper introduces a freeze-drying and gaseous nitrogen-based method to improve SEM imaging while preserving fluorescent signals, enabling better visualization of cellular structures and TEV-host interactions.

The evolution of environmentally mediated social interactions and posthumous spite under isolation by distance

This paper analyzes the evolution of environmentally mediated social interactions and posthumous spite in a spatially structured population under isolation by distance.

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

This study identifies BET inhibition as a potential therapy for BRCA2-deficient pancreatic cancer by showing it enhances autophagy-dependent cell death in these cells.

The shirker's dilemma and the prospect of cooperation in large groups

The paper analyzes how group size affects cooperation in a public good dilemma, finding that cooperation increases with group size under certain conditions, but the probability of public good provision may increase or decrease depending on the cost of cooperation.

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

Interferon regulatory factor 3 upregulates the Treg recruitment factor CCL22 in response to double-stranded DNA in cancer cells

This study identifies IRF3 as a key regulator of CCL22 expression in cancer cells in response to dsDNA, linking STING activation to immunosuppressive mechanisms.

Eusociality through conflict dissolution

The paper explains how maternal influence can lead to voluntary offspring help in eusocial species by dissolving parent-offspring conflict through reproductive division of labor and trade-off alleviation.

The evolution of mechanisms to produce phenotypic heterogeneity in microorganisms

The paper uses theoretical models to show coordinated specialisation is more adaptive than random specialisation in microorganisms under certain environmental conditions.

Group size and collective action in a binary contribution game

The paper analyzes how group size impacts the provision of a public good in a binary contribution game, showing decreasing expected payoffs and probability of success with larger groups.

The evolution of egg trading in simultaneous hermaphrodites

The paper models the evolution of egg trading in simultaneous hermaphrodites, showing it can invade a population under specific conditions involving mate encounter rates, egg production costs, and detection of cheaters.

Group size effects in social evolution

The paper examines how group size influences the evolution of cooperation in games, finding that larger groups reduce stable cooperation but expand the basin of attraction for cooperative outcomes.

Fragmentation modes and the evolution of life cycles

The paper models fragmentation modes in reproduction and finds that life cycles maximizing population growth rate include unicellular propagule production and division into two similar size groups.

Antisocial rewarding in structured populations

The paper investigates how spatial structure affects antisocial rewarding in public goods dilemmas and finds that it can sometimes hinder the evolution of prosocial rewarding.