Y. Yin

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

This study investigates N2O reduction in acidic tropical soils, finding distinct microbial communities and novel taxa associated with N2O reduction at low pH.

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.

The paper investigates how transcription factors recognize DNA dinucleotides through structural analysis, revealing water-mediated mechanisms that enhance specificity beyond mononucleotide recognition.

This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.

This study shows intermittent fasting increases IL-22 production by intestinal ILC3s, promoting beigeing of white adipose tissue and improving metabolic health.

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.

This study uses spatial imaging to analyze Hodgkin lymphoma tumor microenvironments and identifies new biomarkers related to immune cell interactions and checkpoints.

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

The paper identifies BR-responsive gene expression in Arabidopsis root cells using single-cell RNA-sequencing and reveals HAT7 and GTL1 as transcription factors regulating cell elongation.

This study shows that gut microbiota supports liver regeneration by promoting hepatic phospholipid synthesis, with antibiotic-induced dysbiosis impairing this process.

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

This paper identifies a novel C. elegans pathway involving nck-1 and the actin cytoskeleton that mediates defense against bacterial pore-forming proteins, independent of MAPK signaling.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study uses ex vivo drug sensitivity testing to identify treatment responses and vulnerabilities in chronic lymphocytic leukemia patients, showing that pan-PI3Ki and combinations with venetoclax can be effective in idelalisib-refractory/intolerant cases.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

This study identifies novel antibody interfaces through structural analysis, revealing recurrent motifs and enabling their functional validation and optimization.

The paper integrates multi-omics data to uncover molecular interactions between BR and TORC signaling in Arabidopsis, revealing shared regulatory mechanisms in growth and stress responses.

This study shows that brassinosteroids modulate autophagy in Arabidopsis by phosphorylating RAPTOR1B via BIN2 kinase, linking BR signaling to TOR-mediated autophagy regulation.

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

This paper identifies a novel daidzein reductase gene C1-07020 from Clostridium C1 that exhibits bidirectional enzyme activity and is widely distributed in human and animal gut microbiomes, offering new insights into (S)-equol production and potential applications.