Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum
S. H. Saber, M. R. Shaker, J. Sng, N. Yak, S. D. Morrison, S. Pars, H. Zheng, G. Pietrogrande, T. Binder, S. Lu, M. Floetenmeyer, R. Ojha, T. Quirin, J. Ruuska, T. Smura, , M. Joensuu
This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.
bioRxiv · Mar 3, 2023 · PreprintMicrobiology