Allosteric cooperation in β-lactam binding to a non-classical transpeptidase
N. Ahmad, S. Kachhap, V. Chauhan, P. Juneja, K. Sharma, C. K. Bullen, T. Borowski, W. R. Bishai, G. Lamichhane, P. Kumar
The paper identifies an allosteric site in a L,D-transpeptidase that binds the sugar moiety of PG substrates and a second β-lactam molecule, revealing cooperative binding with the catalytic site.
bioRxiv · Sep 6, 2021Biochemistry