Author

S. Kachhap

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Isaacs· 2 shared M. Carducci· 2 shared R. Kumar· 2 shared S. Denmeade· 2 shared A. M. De Marzo· 1 shared A. Mandl· 1 shared A. Newman· 1 shared A. Williams· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. Isaacs

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

S. Jasim, R. Kumar, S. Kim, T. Krueger, I. Coleman, S. Dalrymple, L. Antony, D. Rosen, B. Hanratty, R. Patel, P. Nelson, Z. Aghaei, J. Beumer, M. Haffner, T. Lotan, , W. Brennen

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

bioRxiv · Jan 17, 2024 · PreprintCancer Biology

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

R. Henderson, K. Anasti, K. Manne, V. Stalls, C. Saunders, Y. Bililign, A. Williams, P. Bubphamala, M. Montani, S. Kachhap, J. Li, C. Jaing, A. Newman, D. Cain, X. Lu, , B. F. Haynes

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

bioRxiv · Dec 15, 2023Immunology

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

H. Khan, P. Paul, R. R. Sevalkar, S. Kachhap, B. Singh, D. Sarkar

The paper identifies a regulatory mechanism where CRP and PhoP co-activate virulence genes in M. tuberculosis through protein-protein interactions and promoter recruitment.

bioRxiv · Jun 30, 2022Microbiology

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

N. Ahmad, S. Kachhap, V. Chauhan, P. Juneja, K. Sharma, C. K. Bullen, T. Borowski, W. R. Bishai, G. Lamichhane, P. Kumar

The paper identifies an allosteric site in a L,D-transpeptidase that binds the sugar moiety of PG substrates and a second β-lactam molecule, revealing cooperative binding with the catalytic site.

bioRxiv · Sep 6, 2021Biochemistry

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

J. Mendonca, R. Kumar, O. Owoyemi, K. Boyapati, N. Thomas, S. Kanacharoen, M. Coffey, D. Topiwala, C. Gomes, B. Ozbek, T. Jones, M. Rosen, L. Dong, S. Wiens, W. N. Brennen, , S. Kachhap

bioRxiv · Sep 10, 2020 · PreprintCancer Biology