Author

P. Juneja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Singla· 2 shared B. Chen· 2 shared D. A. Kramer· 2 shared D. D. Billadeau· 2 shared D. J. Boesch· 2 shared E. Burstein· 2 shared Y. Han· 2 shared Z. Chen· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Singla

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural basis for Retriever-SNX17 assembly and endosomal sorting

A. Singla, D. J. Boesch, H. Y. J. Fung, C. Ngoka, A. S. Enriquez, R. Song, D. A. Kramer, Y. Han, P. Juneja, D. D. Billadeau, X. Bai, Z. Chen, E. E. Turer, E. Burstein, B. Chen

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

bioRxiv · Mar 12, 2024Biochemistry

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

D. J. Boesch, A. Singla, Y. Han, D. A. Kramer, Q. Liu, K. Suzuki, P. Juneja, X. Zhao, X. Long, M. J. Medlyn, D. D. Billadeau, Z. Chen, B. Chen, E. Burstein

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

bioRxiv · Jun 6, 2023Cell Biology

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

D. Y.-w. Lin, L. E. Kueffer, P. Juneja, T. E. Wales, J. R. Engen, A. H. Andreotti

This study presents the first structural analysis of full-length BTK, revealing conformational heterogeneity in the PHTH-PRR region and providing insights into BTK activation mechanisms.

bioRxiv · Jun 2, 2023Biophysics

PAM binding ensures orientational integration during Cas4-Cas1-Cas2 mediated CRISPR adaptation

Y. Dhingra, S. K. Suresh, P. Juneja, D. G. Sashital

This study determines the cryo-EM structures of the Cas4-Cas1-Cas2 complex, revealing how PAM binding ensures correct spacer orientation during CRISPR adaptation.

bioRxiv · May 30, 2022Biochemistry

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

N. Ahmad, S. Kachhap, V. Chauhan, P. Juneja, K. Sharma, C. K. Bullen, T. Borowski, W. R. Bishai, G. Lamichhane, P. Kumar

The paper identifies an allosteric site in a L,D-transpeptidase that binds the sugar moiety of PG substrates and a second β-lactam molecule, revealing cooperative binding with the catalytic site.

bioRxiv · Sep 6, 2021Biochemistry

Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine

M. C. Tillman, N. Imai, Y. Li, M. Khadka, C. D. Okafor, P. Juneja, A. Adhiyaman, S. J. Hagen, D. E. Cohen, E. A. Ortlund

This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.

bioRxiv · Feb 18, 2020 · PreprintBiochemistry

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimer

M. Sherekar, S.-W. Han, R. Ghirlando, S. Messing, M. Drew, P. Juneja, H. O'Neill, C. Stanley, D. Bhowmik, A. Ramanathan, S. Subramaniam, D. V. Nissley, W. Gillette, F. McCormick, D. Esposito

This study shows Neurofibromin forms a high-affinity dimer through biochemical and structural analysis, with implications for its function in RAS-MAPK signaling.

bioRxiv · Sep 5, 2019 · PreprintBiochemistry