Author

T. Dimitriu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

E. R. Westra· 3 shared A. Buckling· 2 shared B. Raymond· 2 shared S. van Houte· 2 shared A. C. Matthews· 1 shared A. Darby· 1 shared B. J. Pons· 1 shared E. Kurilovich· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersMicrobiology

E. R. Westra

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defences.

B. J. Pons, T. Dimitriu, E. R. Westra, S. van Houte

The paper shows that translation-inhibiting antibiotics reduce phage amplification on CRISPR-Cas bacteria by blocking phage-encoded anti-CRISPR gene expression.

bioRxiv · Sep 7, 2022 · PreprintMicrobiology

Re-inventing pathogen passage for social microbes

T. Dimitriu, W. Souissi, P. Morwool, A. Darby, N. Crickmore, B. Raymond

This study shows that metapopulation selection can prevent social cheating and improve virulence in Bacillus thuringiensis against resistant hosts.

bioRxiv · Aug 4, 2022 · PreprintEvolutionary Biology

Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity

T. Dimitriu, E. Kurilovich, U. Lapinska, K. Severinov, S. Pagliara, M. D. Szczelkun, E. R. Westra

This study shows bacteriostatic antibiotics promote CRISPR-Cas immunity in Pseudomonas aeruginosa by slowing phage development and allowing more time for immune response.

bioRxiv · May 4, 2021 · PreprintMicrobiology

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens

E. Pursey, T. Dimitriu, F. L. Paganelli, E. R. Westra, S. van Houte

The paper analyzes bacterial genomes to show that CRISPR-Cas systems are associated with fewer antibiotic resistance genes, suggesting they limit horizontal gene transfer of resistance.

bioRxiv · Apr 12, 2021Microbiology

Increased copy number couples the evolution of plasmid horizontal transmission and antibiotic resistance.

T. Dimitriu, A. C. Matthews, A. Buckling

This study shows that plasmids can evolve higher transfer rates and antibiotic resistance when exposed to susceptible hosts, driven by mutations in the copA gene that increase copy number.

bioRxiv · Aug 12, 2020Microbiology

Plasmid transfer is biased towards close kin in bacteria from natural populations.

T. Dimitriu, L. Marchant, A. Buckling, B. Raymond

The paper examines plasmid transfer rates between Escherichia coli isolates and finds that transfer is biased towards genetically similar clones, likely due to shared restriction-modification systems.

bioRxiv · Oct 3, 2018Ecology