Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs
R. Ahmed, N. Majety, K. C. Chan, A. Giwa, J. Heinemann, H. Zhang, J. Margolick, R. Al-Hallaf, P. Paul, D. R. Bell, Y. Song, S. Lee, R. Zhou, R. M. Wolfe, T. Donner, , A. R. A. Hamad
The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.
bioRxiv · May 6, 2023 · PreprintImmunology