R. Zhou

IsRNAcirc: 3D structure prediction of circular RNAs based on coarse-grained molecular dynamics simulation

IsRNAcirc predicts circular RNA 3D structures using coarse-grained molecular dynamics, outperforming template-based methods on a validation set.

Reversible control of kinase signaling through chemical-induced dephosphorylation

This study uses an ABA-induced proximity system to reversibly control kinase signaling by recruiting phosphatases, revealing how phosphatases regulate oncogenic kinases like BCR::ABL1, BRAF(V600E), and MEK1.

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

This study shows that Gγ13 signaling in tuft cells is essential for resolving lung inflammation and promoting recovery after severe injury.

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.

Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutamate export and glutaminase

This study shows that inhibiting glutaminase and xCT in TNBC disrupts redox balance, enhances chemotherapy efficacy, and can be monitored non-invasively using PET.

Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

This study identifies a third interaction between Myo5a and Mlph, involving the exon-G region of Myo5a and Mlph-ABD, which is required for melanosome association.

Extracellular vesicles from patients with coronary artery disease (CAD) demonstrate enhanced pro-coagulatory activity.

This study finds that extracellular vesicles from CAD patients show increased pro-coagulatory activity despite similar numbers to controls, suggesting a role in CAD pathogenesis.

Computational design of N-linked glycans for high throughput epitope profiling

The paper develops a computational method using N-linked glycans to rapidly map epitopes, validated through ELISA, yeast display, and X-ray crystallography using human coagulation factor IXa.

The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Epidermal Growth Factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

The paper shows EGF enhances TNBC cells' response to CAP-activated medium by activating specific EGFR phospho-tyrosines and increasing ROS levels.

Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs

The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

Conformations of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles (SMALPs)

This study compares the stability and conformation of HIV-1 Env in detergents versus SMA lipids, showing SMA preserves the pretriggered state better at room temperature.

An efficient stochastic steering strategy of magnetic particles in vascular networks

This paper develops a multi-physics model and stochastic magnetic steering strategy to enhance drug particle mobility and navigation in vascular networks.

Pathogenesis of Breakthrough Infections with SARS-CoV-2 Variants in Syrian Hamsters

This study investigates SARS-CoV-2 variant pathogenesis in Syrian hamsters, finding that prior infection reduces disease severity upon reinfection with different variants.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

In vitro floral development in poplar: Insights into seed trichome and trimonoecy regulation

The paper develops an in vitro flowering system in poplar to study reproductive traits like sex, seed trichomes, and trimonoecy.

Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

This study examines how SARS-CoV-2 variants infect nasal and olfactory tissues, showing differences in tropism, immune response, and regeneration across age groups.

Death-seq identifies regulators of cell death and senolytic therapies

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

Waning immune responses against SARS-CoV-2 among vaccinees in Hong Kong

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.