BiochemistrybioRxiv
Evolution-Inspired Engineering of Anthracycline Methyltransferases
P. Dinis, H. Tirkkonen, V. Siitonen…·M. Metsa-Ketela
The paper engineers anthracycline methyltransferases by combining regions from four subfamilies to expand their catalytic capabilities and understand factors influencing substrate specificity and reaction outcomes.
DOI 10.1093/pnasnexus/pgad009