Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers
A. Voronka, B. Efimenko, S. Oreshkov, M. Franco, Z. Fleischmann, V. Yurov, A. Trufanova, V. Timonina, N. Ree, A. Zalevsky, E. Penfrat, T. Junier, A. Agranovsky, K. Khrapko, K. Gunbin, , K. Popadin
The paper analyzes SARS-CoV-2 mutagenesis, showing C>U and G>U biases drive amino-acid substitutions from CG-rich losers to U-rich gainers, with implications for vaccine design.
bioRxiv · Aug 22, 2022 · PreprintEvolutionary Biology