Evolutionary BiologybioRxivPreprint
Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers
A. Voronka, B. Efimenko, S. Oreshkov…·K. Popadin
The paper analyzes SARS-CoV-2 mutagenesis, showing C>U and G>U biases drive amino-acid substitutions from CG-rich losers to U-rich gainers, with implications for vaccine design.
DOI 10.1101/2022.08.22.504819