Improving genome quality through artificial truncating purifying selection using heat shock: case of carps
A. V. Kuzmin, E. Vinogradov, D. Balashov, E. Kozenkova, D. Iliushchenko, A. G. Mikhailova, N. Patlay, E. Zakharenko, I. I. Kozenkov, I. Ptashnik, V. N. Timonina, E. Tretiakov, Y. Galimov, C. R. Haag, B. Efimenko, , K. Popadin
The paper investigates using heat shock to induce purifying selection in carp to reduce deleterious mutations, finding that fitness drops more in mutated lines but with weak and unstable effects.
bioRxiv · Jan 20, 2023 · PreprintEvolutionary Biology