RIPK3 promoter hypermethylation in hepatocytes protects from bile acid induced inflammation and necroptosis
J. Hoff, L. Xiong, T. Kammann, S. Neugebauer, J. M. Micheel, M. Ghait, S. D. Deshmukh, A. Press, M. Bauer, N. Gassler
The paper shows that RIPK3 promoter hypermethylation in hepatocytes reduces RIPK3 expression, protecting against bile acid-induced inflammation and necroptosis, but RIPK3 induction may signal danger in cholestatic liver diseases.
bioRxiv · Jan 15, 2021 · PreprintBiochemistry