M. Bauer

Diffusing protein binders to intrinsically disordered proteins

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

Enhanced Visualization of Influenza A Virus Entry Using Virus-View Atomic Force Microscopy

This study uses ViViD-AFM to visualize influenza A virus entry into cells, revealing nanoscale interactions and endocytosis mechanisms.

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Spatiotemporal visualization of DNA replication by click chemistry reveals bubbling of viral DNA in virion formation

The paper uses click chemistry to visualize DNA replication in human adenovirus, showing distinct roles of early and late-replicated viral DNA in virion formation.

Multiple myeloma long-term survivors display sustained immune alterations decades after first line therapy

This study examines immune changes in multiple myeloma survivors years after treatment, finding sustained immune alterations linked to residual disease and therapy.

Fit by design: Developing substrate-specific seed mixtures for functional dike grasslands

The paper tests seed-substrate combinations for restoring functional dike grasslands, finding that while vegetation develops as desired, recovery debt remains and south-facing plots struggle due to drought.

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

This study identifies genes and pathways involved in senescence escape in NRAS mutant melanoma using multi-omics approaches.

H2A.X mutants exhibit enhanced DNA demethylation in Arabidopsis thaliana

This study shows that H2A.X mutants in Arabidopsis thaliana exhibit reduced CG DNA methylation in endosperm, primarily in transposons and intergenic regions, suggesting H2A.X's role in maintaining methylation homeostasis.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

An optimised method for bacterial nucleic acid extraction from positive blood culture broths for whole genome sequencing, resistance phenotype prediction and downstream molecular applications

This paper optimizes DNA extraction from blood culture broths for whole genome sequencing and resistance prediction, showing high accuracy for common pathogens and potential for rapid diagnostics.

Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release.

This study identifies RNA aptamers secreted by Gram-positive bacteria that activate the STING pathway to induce IL-1β release in human macrophages.

Arrayed multicycle drug screens identify broadly acting chemical inhibitors for repurposing against SARS CoV 2

The paper screens 5440 compounds to identify chemical inhibitors effective against multiple coronaviruses, including SARS-CoV-2, finding several FDA-approved drugs with potential for repurposing.

RIPK3 promoter hypermethylation in hepatocytes protects from bile acid induced inflammation and necroptosis

The paper shows that RIPK3 promoter hypermethylation in hepatocytes reduces RIPK3 expression, protecting against bile acid-induced inflammation and necroptosis, but RIPK3 induction may signal danger in cholestatic liver diseases.

Geometric and Topological Approaches to Shape Variation in Ginkgo Leaves

The paper quantifies leaf shape variation in modern and fossil Ginkgo leaves using geometric and topological methods, finding that size and furrow depth are primary factors, with topological methods distinguishing shoot types.

The E3 ubiquitin ligase Mind bomb 1 enhances nuclear import of viral DNA by inactivating a virion linchpin protein that suppresses exposure of virion pathogen-associated molecular patterns

The paper shows that Mib1 ubiquitinates viral protein V to enable adenovirus DNA nuclear import, preventing innate immune activation.

Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and correlation to tissue damage

The paper maps SARS-CoV-2 RNA distribution in 11 deceased COVID-19 patients and correlates it with tissue damage and systemic inflammation.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Burkholderia pseudomallei clinical isolates are highly susceptible in vitro to cefiderocol, a novel siderophore cephalosporin

This study evaluates cefiderocol's in vitro activity against 271 Burkholderia pseudomallei isolates, finding high susceptibility with MIC90 values of 1 and 16 mg/L for primary and subsequent isolates, respectively.

Heme induces innate immunity memory

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

Use of IFNγ/IL10 ratio for stratification of hydrocortisone therapy in patients with septic shock

This paper identifies the IFNγ/IL10 ratio as a biomarker to guide hydrocortisone therapy in septic shock, showing improved survival when treatment aligns with the ratio's prediction.