A super sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair
K. Nishimura, R. Yamada, S. Hagihara, R. Iwasaki, N. Uchida, T. Kamura, K. Takahashi, K. U. Torii, T. Fukagawa
The paper develops an improved auxin-inducible degron system with an engineered auxin-TIR1 pair that reduces auxin concentration requirements and enables efficient protein depletion in human and mouse cells.
bioRxiv · Jan 20, 2020Bioengineering