K. Nishimura

Chromosome-level genome assemblies for two quinoa inbred lines from northern and southern highlands of Altiplano where quinoa originated

This paper presents high-quality chromosome-level genome assemblies for two highland quinoa inbred lines using PacBio HiFi sequencing and dpMIG-seq, enabling functional genomics research and gene identification for environmental adaptation and domestication.

Cytosolic heme metabolism by alternative localization of heme oxygenase 1 in plant cells

The paper identifies two HO1 transcripts in Arabidopsis and rice with distinct subcellular localizations and shows that cytosolic heme metabolism occurs during etiolation and early development.

Influence of High-Fat Diet and Sex on Connective Tissue in Carpal Tunnel Syndrome

This study investigates how a high-fat diet and sex influence SSCT thickening and fibrosis in a rabbit model of carpal tunnel syndrome, finding sex-dependent gene expression changes and higher CTS incidence in men under metabolic stress.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

Local induction of IAA5 and IAA29 promotes DNA damage-triggered stem cell death in Arabidopsis roots

The paper shows that IAA5 and IAA29 promote DNA damage-triggered stem cell death in Arabidopsis roots by suppressing auxin signaling.

The double-layered structure of amyloid-β assemblage on GM1-containing membranes catalytically promotes fibrillization

This study identifies a double-layered Aβ structure on GM1 membranes that catalyzes fibril formation without becoming fibrils itself.

Iron Deficiency Induces Heart Failure with Ectopic Cardiac Calcification in Mice with Metabolic Syndrome

This study shows that iron deficiency in mice with metabolic syndrome causes heart failure with ectopic cardiac calcification, which is reduced by etidronate.

Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

This study shows plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts through the ESCRT pathway and Ca2+-p53 axis.

Dermal macrophages set pain sensitivity by modulating tissue NGF levels through SNX25-Nrf2 signaling

The paper identifies SNX25 in dermal macrophages as a regulator of NGF levels through Nrf2 signaling, affecting pain sensitivity in mice.

DNA damage inhibits root growth by enhancing cytokinin biosynthesis in Arabidopsis thaliana.

This study shows DNA damage in Arabidopsis roots increases cytokinin synthesis, which suppresses auxin transport and reduces root growth.

A super sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair

The paper develops an improved auxin-inducible degron system with an engineered auxin-TIR1 pair that reduces auxin concentration requirements and enables efficient protein depletion in human and mouse cells.

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

The paper identifies ZP1 cross-linking as crucial for human ZP assembly and explores its modulation by fucosylation and zinc sparks, suggesting it as a target for non-hormonal contraception.

Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors

The paper compares epigenetic differences in human iPSCs generated by three different vectors and finds Sendai virus generates the fewest aberrant methylation sites.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

This study shows TET2 binding to enhancers in hematopoietic cells supports transcription factor recruitment, and its loss disrupts chromatin binding of CDX4, linking epigenetic regulation to disease.