ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis
T. Lodhiya, A. Palande, A. Veeram, G. Larrouy-Maumus, D. J. Beste, R. Mukherjee
The paper investigates how aminoglycoside and fluoroquinolone antibiotics induce cell death in M. smegmatis by increasing TCA cycle flux, ATP production, and ROS, with ATP levels being the primary driver of lethality.
bioRxiv · Sep 11, 2023 · PreprintMicrobiology