BiochemistrybioRxiv
Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain
B. Kleizen, M. van Willigen, M. Mijnders…·I. Braakman
This study reveals early co-translational folding and assembly of CFTR's TMD1 and ICL1 domains, showing how VX-809 enhances this process and supports CFTR function.
DOI 10.1016/j.jmb.2021.166955