BiochemistrybioRxiv
Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
C. R. M. Asquith, G. J. Tizzard, J. M. Bennett…·T. Laitinen
This paper designs and tests 4-anilinoquinoline inhibitors targeting cyclin G-associated kinase (GAK) by analyzing water networks in the ATP binding site.
DOI 10.1002/cmdc.202000150