Endosome dysfunction leads to gain-of-function TLR7 and human lupus
H. Mishra, C. Schlack-Leigers, E. L. Lim, O. Thieck, T. Magg, J. Raedler, C. Wolf, C. Klein, H. Ewers, M. A. Lee-Kirsch, D. Meierhofer, F. Hauck, O. Majer
This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.
bioRxiv · Apr 3, 2023 · PreprintImmunology