Author

T. Mai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

A. A. Bobkov· 1 shared A. De Morree· 1 shared A. L. Cooksy· 1 shared A. Trejo· 1 shared B. M. Conley· 1 shared C. A. Holbrook· 1 shared C. D. Sohl· 1 shared D. A. Matteo· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. A. Bobkov

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Author profile →

2 papers

Recent·Most cited

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

M. Mealka, N. A. Sierra, D. A. Matteo, E. Albekioni, R. Khoury, T. Mai, B. M. Conley, N. J. Coleman, K. A. Sabo, E. A. Komives, A. A. Bobkov, A. L. Cooksy, S. Silletti, J. M. Schiffer, T. Huxford, C. D. Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

bioRxiv · Jan 10, 2024Biochemistry

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

E. Porpiglia, T. Mai, P. Kraft, C. A. Holbrook, A. De Morree, V. D. Gonzalez, K. Hilgendorf, L. Fresard, A. Trejo, S. Bhimaraju, P. K. Jackson, W. J. Fantl, H. M. Blau

This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.

bioRxiv · Apr 29, 2022Cell Biology