Author

S. Silletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Approach:mechanistic / dynamical model· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. A. Komives· 4 shared J.-H. Weng· 2 shared S. S. Taylor· 2 shared A. A. Bobkov· 1 shared A. L. Cooksy· 1 shared A. M. V. West· 1 shared B. Bibel· 1 shared B. M. Conley· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiochemistry

E. A. Komives

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

M. Mealka, N. A. Sierra, D. A. Matteo, E. Albekioni, R. Khoury, T. Mai, B. M. Conley, N. J. Coleman, K. A. Sabo, E. A. Komives, A. A. Bobkov, A. L. Cooksy, S. Silletti, J. M. Schiffer, T. Huxford, C. D. Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

bioRxiv · Jan 10, 2024Biochemistry

Capturing differences in the regulation of LRRK2 dynamics and conformational states by small molecule kinase inhibitors

J.-H. Weng, W. Ma, J. Wu, S. Silletti, J. A. McCammon, S. S. Taylor

This study uses simulations and HDX-MS to analyze how two LRRK2 inhibitors affect the protein's conformational dynamics and kinase activity.

bioRxiv · Oct 24, 2022Biochemistry

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

B. Bibel, E. Elkayam, S. Silletti, E. A. Komives, L. Joshua-Tor

The paper shows that miRNA-loaded Ago2 binding to target RNA primes its EI for CK1-mediated phosphorylation, which facilitates target release through electrostatic effects.

bioRxiv · Jan 6, 2022Biochemistry

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

S. H. Schmidt, J.-H. Weng, P. C. Aoto, D. Boassa, S. Mathea, S. Silletti, J. Hu, M. Wallbott, E. A. Komives, S. Knapp, F. W. Herberg, S. S. Taylor

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

bioRxiv · Jul 13, 2020Biochemistry

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein

Q. Ye, A. M. V. West, S. Silletti, K. D. Corbett

This study determines the structure and self-assembly of the SARS-CoV-2 nucleocapsid protein, identifies structured regions in disordered domains, and maps amino acid substitutions across viral genomes.

bioRxiv · May 17, 2020Biochemistry

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

P. Galaz-Davison, J. A. Molina, S. Silletti, E. A. Komives, S. H. Knauer, I. Artsimovitch, C. A. Ramirez-Sarmiento

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

Biophysical Journal · Jan 1, 2020Peer-reviewedBiophysics