H. M. Blau

The paper identifies distinct functions of VEGFA from different cell types in skeletal muscle regeneration through time-resolved transcriptomic analysis and functional experiments.

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

This study identifies elevated CD47 in aged muscle stem cells as a marker of dysfunction and shows that targeting CD47 improves regeneration in aged mice.

This study maps tumor heterogeneity in pediatric rhabdomyosarcoma using single-cell data, revealing developmental signatures and identifying the RAS pathway as a therapeutic target.

This study shows that upregulating TRF2 in DMD cardiomyocytes from iPSCs increases telomere length and improves cell survival.

The paper develops ConTraX, a pipeline to track contractile dynamics in single hiPSC-CMs, revealing maturation patterns through high-dimensional clustering.

This study identifies ciliary Hedgehog signaling as critical for muscle stem cell regeneration, showing that restoring it in aged mice improves muscle repair.

This study identifies Oncostatin M as a secreted niche factor that induces muscle stem cell quiescence and maintains their regenerative capacity.