T. Martinu

The paper identifies CD4+CD57+PD1+ T cells in lung transplant recipients that predict allograft dysfunction and are associated with fibrosis in both human and mouse models.

The paper identifies two macrophage subsets in lung transplant recipients associated with acute and chronic allograft dysfunction using single-cell RNA sequencing.

The paper uses scRNA-seq to analyze BAL cells from lung transplant patients, identifying pro-inflammatory macrophage subsets linked to allograft dysfunction.

This study shows that ex vivo delivery of regulatory T cells to donor lungs before transplantation can suppress alloimmune responses and improve lung graft outcomes in a rat model.

This study shows that defective COPI transport of STING due to COPA mutations leads to immune dysregulation and type I interferon signaling in COPA syndrome.